Prontosan > Polyhexanide (PHMB)


 

Polyhexanide (PHMB)
Promotes Healing Minimises Bioburden

 

PHMB is active against gram – and gram + bacteria, fungi and yeast including MRSA, Pseudomanas aeruginosa, VRE etc.
 
PHMB has been in general use for about 60 years with no evidence of resistance. It is used in cosmetics, contact lens solution, swimming pools etc
 
Mode of action
 
PHMB acts by electrostatic interactions, this mechanism is based on the character of the molecule and the distribution of electrical charges. This interferes with the bacterial cell metabolism, by prohibiting the cells ability to absorb any nutrients or dispose of waste products. This effectively killing the bacteria without damaging surrounding healthy cells.
 
PHMB is not adsorbed by cells and tissue , nor absorbed by them, and therefore cannot interfere with the metabolism of the body.

Advantages of PHMB

  • excellent skin tolerance
  • non toxic, non irritant
  • hypoallergenic
  • no known resistance
  • suitable for long term use, not absorbed
  • can be used up to 8 weeks (Prontosan 350ml Solution & Gel)
  • no inhibition of granulation tissue unlike antiseptics